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GLaDOS is the central core designed to control, guide, and oversee the Aperture Enrichment Center. With the ability to shift and move facilities and various chambers, GLaDOS is able to achieve a seamless and almost infinite testing design whilst residing in the Central AI Chamber.
Cave Johnson is the founder of Aperture Science, which was built from Aperture Science Innovations. He was briefly mentioned in Portal, but makes a more prominent appearance in Portal 2, in the form of tape recordings he leaves behind. His current status and whereabouts are unknown, presumed dead.